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Biomolecular spectroscopic imaging for living cells has attracted much attention as a way to understand biological systems and detect biological events on a cellular scale. For a label-free, non-destructive spectroscopic imaging method, plasmonic resonance energy transfer (PRET)-based molecular imaging using plasmonic nanoparticles as a probe has been proposed. We propose a metasurface-driven multiplexed nanospectroscopy based on PRET to overcome the limitation of the previous plasmonic nanoparticle based-PRET imaging. Our probing method of biological light-matter interactions in metasurfaces via multiplexed PRET nanospectroscopy will enable real-time monitoring of cellular communications, continuous tracking of chemicals or secretome profiling of live cells, real-time monitoring of exosomes, understanding systems biology, and precision molecular diagnostics.
Metasurface-enhanced molecular diagnostics
The global impact of the COVID-19 pandemic caused by SARS-CoV-2 has led to a need for quick and accurate pathogen detection. Therefore, developing inexpensive point-of-care devices is crucial to identifying infected individuals and preventing the spread of the disease. Polymerase chain reaction (PCR) is widely used in molecular diagnosis, genotyping, and gene expression analysis, and is considered the gold standard for nucleic acid amplification. We develop a low-cost photonic PCR device that uses a titanium nitride (TiN)-based meta-absorber to heat and cool the PCR mixture rapidly. With the help of a compact single infrared LED source, DNA amplification can be achieved within 5 minutes. This metasurface-enhanced photonic PCR platform has the potential to become a new molecular diagnostic tool for point-of-care testing devices.
Quantum-enhanced molecular spectroscopy
Quantum mechanical perspective on light-matter interactions with specifically designed optical cavity, or cavity quantum electrodynamics, can offer insight into the relationship between atomic states of matter and electromagnetic modes in optical cavity. We are witnessing that the peculiar hybridized energy state between atom and photon, or partial matter and partial light at the same time, can be detected using general optical microscope at room temperature, though, relatively few applications of strong coupling effects have been reported. We develop quantum metasurfaces for plexcitonic and polaritonic strong coupling effects in chemical and biomedical applications. The strong coupling effect can be utilized as a tool to modify chemical reaction landscapes using the vibrational state of molecule and hot electron of plasmon in chemistry. In addition, strong coupling-induced quantum plasmonic biosensor not only can detect quantum coherence effects, but also improve detection sensitivity beyond the limit of classical sensors.
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